Raised serum immunoglobulin E in Wegener's granulomatosis.
نویسندگان
چکیده
Five patients with Wegner's granulomatosis were found to have significantly raised serum immunoglobulin E (IgE) levels. The rise in IgE was not related to the extent of clinical involvement, was not part of a generalized serum immunoglobulin rise, and was not associated with eosinophilia. Raised serum IgE may be a clue to the pathogenesis of this disease.
منابع مشابه
Genetic associations of variants of the high affinity receptor for immunoglobulin E in Wegener's granulomatosis.
Immunoglobulin E (IgE) and the high affinity IgE receptor (FcepsilonRI) have been suggested to contribute to the pathogenesis of autoimmune disorders. Their role in Wegener's granulomatosis (WG) are, however, poorly recognized. We sought a genetic association between laboratory markers for the disease, i.e. anti-proteinase 3 antibodies (anti-PR3), anti-myeloperoxidase antibodies, anti-cyclic ci...
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عنوان ژورنال:
- Annals of the rheumatic diseases
دوره 35 4 شماره
صفحات -
تاریخ انتشار 1976